Perbandingan Dosis Induksi dan Pemeliharaan Propofol Pada Operasi Onkologi Mayor yang Mendapatkan

Artikel Jurnal Perbandingan Dosis Induksi dan Pemeliharaan Propofol Pada Operasi Onkologi Mayor yang Mendapatkan

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Abstract

Background: General anesthesia is the most frequently performed anesthetic technique compared to other anesthetic techniques. Intravenous Total Anesthesia using propofol has been widely developed, because of the reduced incidence of PONV, cheaper anesthesia costs, and rapid recovery time. Various techniques, tools and medicines were studied to reduce the dose of propofol which required duration of surgery due to the dangerous side effects of propofol, known as PRIS (Propofol Related Infusion Syndrome), which can cause high morbidity and mortality.

Purpose: To compare the induction dose and maintenance of propofol needed intraoperatively between the gabapentin group and the control group. Furthermore, the results of the study can be used generally in the use of gabapentin as an acute drug in the perioperative period.

Method: This study was a double blind clinical trial. This research technique can control the expectations and manipulations of research subjects on research procedures so that they can produce valid and reliable results. The study was divided into two groups, the gabapentin group and the control group. 32 samples of each group had undergone major oncology surgery with the same total intravenous anesthetic technique with TCI.

Result: The induction dose of the gabapentin group had 1.15 mg / kg compared to the control group which had a median of 1.48 mg / kg (p <0.001). The maintenance dose of the gabapentin group had a median of 93.27 mcg / kg / minute compared to the control group which had a median of 123.80 mcg / kg / minute (p <0.001).

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