Jurnal Internasional Efek Probiotik pada Sepsis Onset Awitan pada Bayi Sangat Prematur: Uji Klinis Acak

Jurnal Internasional

Efek Probiotik pada Sepsis Onset Awitan pada Bayi Sangat Prematur: Uji Klinis Acak
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Latar Belakang Sepsis onset lambat adalah komplikasi prematuritas yang sering, terkait dengan peningkatan mortalitas dan morbiditas. Probiotik dapat mencegah sepsis onset lambat pada bayi prematur. Tujuan dari penelitian ini adalah untuk menentukan efek profilaksis probiotik oral dalam pencegahan sepsis onset lambat pada bayi yang sangat prematur. Bahan dan Metode Penelitian ini adalah uji coba terkontrol secara acak, double blinded, plasebo. Delapan puluh bayi prematur lahir di < 32 weeks gestation weighing 1,000- 1,500 gr randomly assigned in intervention and control groups. From soon after the start of feeds, intervention group received Pedilact drop, which was a probiotic and control group received distilled water (DW) as placebo, 1 drop per kg of body weight every 12 hours, made by Zist-Takhmir, Iran Company. After data collection incidence of late onset sepsis, mortality, time to establish full enteral feeding and duration of hospitalization were compared between two groups. Results Cause of hospitalization in all patients was respiratory distress and prematurity. The incidence of late sepsis and death in the intervention group was lower than the control group, which was significant. The mean time to establish full enteral feeding in the probiotic group was lower than the control group. No case of necrotizing enterocolitis was observed. There was no difference in terms of days of hospitalization among two groups (P>0,05). Kesimpulan Menurut hasil, penggunaan probiotik profilaksis dapat mengurangi kejadian sepsis onset lambat dan mortalitasnya. Dengan mengonsumsi probiotik bayi prematur bisa mencapai asupan enteral penuh dalam waktu yang lebih singkat, tetapi lamanya rawat inap tidak berkurang.

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